Supplement Interaction Checker
Add the supplements you take to see which combinations are safe, which boost each other, and which you should never take together.
Your Stack
Add at least 2 supplements above to check for interactions.
⚠️ Interactions to Avoid
✅ Good Combinations
This tool is for educational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or combining supplements — especially if you take prescription medication.
Full Supplement Database
Browse all 82 supplements below — timing, category, and a quick summary for each.
Supports bone health, immune function, and mood regulation.
morning · with food
Directs calcium to bones and away from arteries. Essential companion to D3.
morning · with food
Powerful antioxidant supporting immunity, collagen synthesis, and iron absorption.
morning
Essential for energy metabolism, nerve function, and red blood cell formation.
morning
Highly bioavailable magnesium form for relaxation, sleep quality, and muscle function.
evening
Energizing magnesium form that supports ATP production and reduces muscle fatigue.
morning · with food
Essential mineral for immunity, testosterone production, and wound healing.
evening · with food
Essential mineral for oxygen transport, energy, and cognitive function.
morning
Essential for strong bones, muscle contractions, and nerve signaling.
evening · with food
Critical for thyroid hormone production, metabolism, and brain development.
morning · with food
Antioxidant mineral supporting thyroid function and immune health.
morning · with food
Critical for DNA synthesis, methylation, and neural tube development.
morning
The most researched supplement for strength, power output, and muscle growth.
morning
Fast-absorbing complete protein ideal for muscle repair and growth after training.
morning
Slow-digesting protein that provides sustained amino acid release — ideal before sleep.
before_sleep
Increases muscle carnosine to buffer lactic acid and extend high-intensity performance.
morning · with food
Boosts nitric oxide production for better blood flow, pumps, and aerobic endurance.
afternoon
Replenishes minerals lost in sweat to maintain hydration, performance, and prevent cramps.
afternoon
Supports joint health, skin elasticity, tendon repair, and gut lining integrity.
morning
Essential fatty acids supporting brain function, inflammation reduction, and heart health.
morning · with food
Promotes nerve growth factor (NGF) synthesis, supporting memory, focus, and neuroplasticity.
morning · with food
Increases acetylcholine levels for enhanced memory, focus, and mind-muscle connection.
morning
Promotes calm, focused alertness without drowsiness. Classically paired with caffeine.
morning
The world's most widely consumed stimulant — enhances alertness, focus, and physical performance.
morning
Adaptogen that reduces cortisol, supports stress resilience, testosterone, and sleep.
evening · with food
The only magnesium form shown to meaningfully cross the blood-brain barrier, improving memory and sleep.
before_sleep
Regulates the circadian sleep-wake cycle. Most effective for jet lag and shifting sleep timing.
before_sleep
Amino acid that lowers core body temperature to facilitate deep, restful sleep.
before_sleep
Inhibitory neurotransmitter precursor that may promote relaxation and reduce anxiety.
before_sleep
Natural flavonoid from chamomile that binds GABA-A receptors to promote relaxation and sleep.
before_sleep
Beneficial bacteria that support gut microbiome diversity, digestion, and immune function.
morning
Non-digestible fibers that selectively feed beneficial gut bacteria and promote microbiome diversity.
morning · with food
Plant alkaloid that activates AMPK to improve blood sugar regulation and metabolic health.
lunch · with food
Supports mitochondrial ATP production, antioxidant defense, and cardiovascular health.
morning · with food
Polyphenol that activates sirtuin longevity pathways and provides cardiovascular protection.
morning · with food
Precursors to NAD+, supporting cellular energy, DNA repair, and longevity signaling.
morning
Potent anti-inflammatory and antioxidant compound from turmeric root.
morning · with food
Dramatically enhances bioavailability of curcumin and certain other nutrients.
morning · with food
All eight essential B vitamins supporting energy metabolism, brain function, and stress response.
morning · with food
Precursor to glutathione — the body's master antioxidant. Supports liver, lung, and immune health.
morning · with food
Fat-soluble antioxidant that protects cells from oxidative damage and supports immune and skin health.
morning · with food
Essential for vision, immune defence, skin cell turnover, and reproductive health.
morning · with food
Cofactor in over 100 enzyme reactions including neurotransmitter synthesis, hormone regulation, and amino acid metabolism.
morning · with food
B-vitamin essential for hair, nail, and skin integrity, and for metabolising carbohydrates, fats, and proteins.
morning
Highly bioavailable magnesium form that also supports bowel regularity and digestive comfort.
beforeSleep
Combines magnesium with taurine for cardiovascular health, blood pressure regulation, and blood sugar support.
evening · with food
Very low bioavailability magnesium form used primarily as a laxative, not for deficiency correction.
evening
Essential coenzyme for converting carbohydrates into energy. Critical for nerve and heart function.
morning · with food
Herbal supplement often used for mood and depression.
morning · with food
Essential trace mineral for energy and iron metabolism.
morning · with food
Powerful antioxidant known for metabolic support.
morning
Medication for treating hypothyroidism.
early_morning
Transports fatty acids into mitochondria for energy production; supports cardiovascular health and exercise recovery.
morning
Adaptogenic herb that reduces cortisol, combats fatigue, and enhances mental and physical performance under stress.
morning
Potent plant flavonoid with antioxidant, anti-inflammatory, and senolytic properties — clears damaged cells to support healthy aging.
morning · with food
Direct serotonin precursor that improves mood, reduces anxiety, and promotes deeper sleep without dependence.
evening
Naturally occurring compound that rebuilds cartilage, reduces joint pain, and may slow osteoarthritis progression.
morning · with food
Cellular messenger that improves insulin sensitivity, supports mood (PCOS, OCD, anxiety), and regulates reproductive hormones.
morning
Ancient tree extract that improves circulation to the brain, enhances memory and processing speed, and reduces age-related cognitive decline.
morning · with food
Anthocyanin-rich berry that reduces cold and flu severity and duration by inhibiting viral replication and boosting immune response.
morning · with food
Liver-protective herb that promotes liver cell regeneration, reduces inflammation, and supports detoxification pathways.
with_meals · with food
Conditionally essential amino acid supporting heart function, neurological health, exercise performance, and mitochondrial efficiency.
morning
Ayurvedic herb that enhances memory formation, speeds information processing, and reduces anxiety through neurotrophic and antioxidant mechanisms.
with_meals · with food
Key phospholipid in neuronal membranes that improves memory, reduces cortisol, and supports ADHD and age-related cognitive decline.
with_meals · with food
Potent senolytic flavonoid found in strawberries that clears senescent cells, crosses the blood-brain barrier, and activates longevity pathways.
morning · with food
Universal antioxidant that regenerates vitamins C and E, improves insulin sensitivity, reduces nerve damage, and chelates heavy metals.
morning
Marine carotenoid 6,000x more potent than vitamin C as an antioxidant — protects skin, eyes, muscles, and mitochondria from oxidative damage.
with_meals · with food
Natural polyamine that induces autophagy (cellular self-cleaning), linked to reduced cardiovascular mortality and cognitive preservation with aging.
morning
Organic sulfur compound that reduces joint inflammation, muscle soreness, supports collagen synthesis, and enhances antioxidant capacity.
morning · with food
Natural glycosaminoglycan that lubricates joints, hydrates skin from within, and reduces osteoarthritis pain by restoring synovial fluid.
with_meals · with food
The 'mushroom of immortality' — adaptogenic fungi that modulates immunity, reduces fatigue, calms the nervous system, and supports liver health.
evening · with food
Medicinal fungus that boosts ATP synthesis, increases VO₂ max, improves oxygen utilization, and reduces fatigue in both athletes and older adults.
morning
Royal adaptogen with 2,000 years of clinical use — enhances physical and cognitive performance, supports immunity, libido, and blood sugar control.
morning
Andean root that enhances libido, supports hormonal balance, improves exercise endurance, and reduces menopause symptoms without altering estrogen or testosterone levels.
morning · with food
Blend of enzymes (protease, lipase, amylase, lactase) that improves macronutrient digestion, reduces bloating, and enhances nutrient absorption.
with_meals · with food
Soluble fiber from Plantago ovata that lowers LDL cholesterol, stabilizes blood sugar, promotes regularity, and feeds beneficial gut bacteria.
with_meals · with food
Essential B vitamin for cellular energy production, activating other B vitamins, protecting against oxidative stress, and preventing migraines.
morning · with food
Essential B vitamin that raises HDL cholesterol, supports NAD+ production, improves skin barrier, and aids DNA repair. Available as niacin or nicotinamide.
with_meals · with food
Essential B vitamin required for Coenzyme A synthesis — central to energy metabolism, adrenal hormone production, and wound healing.
morning · with food
Leucine, isoleucine, and valine — essential amino acids that prevent muscle breakdown, stimulate muscle protein synthesis, and reduce exercise fatigue.
before_workout
Most abundant amino acid in the body — critical for gut barrier integrity, immune function, muscle recovery, and reducing intestinal permeability (leaky gut).
morning
A methyl donor that lowers homocysteine, supports cellular methylation, liver detoxification, and creatine synthesis.
morning · with food
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